A map of the Great (Celilo) Falls of the Columbia River in Washington and Oregon. "We landed at Some distance above the mouth of this river and Capt. Lewis and my Self Set out to view this river above its mouth," Clark wrote on Oct. 22, 1805.
Lewis and Clark braved the unknown waters of the Missouri to chart America's future. As we approach the 200th anniversary of their sojourn, TIME reflects upon their sacrifice and achievement