COVER
The United States of Amerijuana (Nation)
Don't call it pot; it's "medicine" now. Dealers are caregivers, and buyers are patients ...
Inside Colorado's Marijuana Industry
Photos: One of 14 states that allows some form of medical marijuana, the state has seen a burst of business activity around the sale and distribution of grass
The Science of Pot (Nation)
The lore is giving way to fact — and the news is mixed
ESSAY
A Careless Man: What the Bush Memoir Reveals (Commentary / In the Arena)
Former President George W. Bush's new memoir, Decision Points, is telling and well written, but his overmatched presidency was a mess
Eureka!
One thing technology can't give us is time for serendipitous discovery. Why we need to reinvent free time
NATION
The Future of Detroit: How to Shrink a City (The Well / Assignment Detroit)
Detroit once thrived on bigness, but now it has to leave that idea behind. The secret of Rust Belt urban revival: smaller is better. If you want a healthy, bustling city, huddled masses are a good thing
Detroit Made Small
Photographer Olivo Barbieri brings his startling tilt-shift technique to the Motor City to illustrate TIME's story on the city's shrinkage
Detroit's Future: What Would You Do?
Nine takes on what should be the priorities for the future of the city
A Green Vision (The Well / Assignment Detroit)
Bringing Dogs to Heal: Care for Veterans with PTSD (The Well / Veterans)
It has taken nearly a decade of war--and the lack of a cure for posttraumatic stress disorder--to get officials to study the benefits of giving service animals to mentally ailing soldiers and veterans
Video: How Dogs Help Veterans Cope with PTSD
Struggling with post-traumatic stress, veteran David Sharpe says he found a dog at a shelter that saved his life. Now, with a group called P2V, he pairs other vets with rescued pets
Woman Power: The Rise of the Sheconomy (The Well / The Economy)
How women are using their rapidly increasing spending power to impel changes in the way companies operate
WORLD
Postcard from Fort McMurray
As Canada mines the world's second biggest oil reserves, one indigenous group looks to James Cameron for help. Digging deep into the oil-sands debate
The Second Calamity (The Well / World)
Rains bring Haiti's quake victims a new scourge: cholera
TO OUR READERS
What We Learned in Detroit
Assignment Detroit: From a house in the city, Time Inc. magazines covered Detroit's struggle to survive. The moral: the city brims with tales of shock, inspiration and hope
LETTERS
Inbox (Inbox)
ARTS & ENTERTAINMENT
After a Century of Silence: Twain Speaks (Books)
Mark Twain returns with the unexpurgated, unabridged version of his unblushing memoir
The Man Who Couldn't Stop Running (Books)
The author of Seabiscuit returns with another epic of long odds and unbreakable spirit
Crazy Train (Movies)
Blue collar heroes must stop a speeding locomotive. This sounds like a job for Denzel Washington
Four Lions: What's So Funny About Terrorists? (Movies)
English satirist Chris Morris creates explosive mischief out of a gang of would-be bombers
Q&A Josh Groban (Q&A)
SOCIETY
Pilgrim's Progress: Shaking Up the Turkey Dinner Tradition (Life / Taste of America)
Forget the obligatory Butterball. New trends are making Thanksgiving a movable feast
Thanksgiving Recipes: Turkey-Day Alternatives
How three foodies are breathing fresh life into stale traditions
Honey, Can You Hear Me Now? (Life / Marriage)
Smart-phone apps can help you plan a wedding or conduct an affair. But can they rescue your marriage?
Greener Dishwashing: A Farewell to Phosphates (Life / Going Green)
Banning phosphates in detergents makes for cleaner water if not always cleaner dishes
SPECIAL SECTION
Raising India: Why More Infrastructure Isn't Enough (Global Business / Economic Development)
Investors are funding airports, roads and utilities. But basic services are lagging
Can China Tap the Brake? (Global Business / Investment Horizon)
Once a growth manager, Beijing now has to slow things down. The task is a tricky one
Kno Wants a Slice of Apple (Global Business / Small Business)
Chegg.com's Osman Rashid says his e-textbook tablet can take the iPad to school
Business Books (Global Business)
The 30-year history of the 2007-09 financial crisis. How Wall Street fed the sleazy subprime-mortgage industry
ALSO IN THIS ISSUE
The 50 Best Inventions Of the Year (The 50 Best Inventions Of The Year)
Flying cars! Jet packs! Lasers that zap malaria-carrying mosquitoes! Here are 2010's biggest (and coolest) breakthroughs in science, technology and the arts
Video: The Best Inventions
The Future of Content (The Well / TIME 100 Roundtable)
In a world of infinite content online — most of it accessible for free — how do creators find audiences and get paid?
Person of the Year
TIME asked past TIME 100 honorees whom they would choose for 2010. The nominations are in
Who Will Be TIME's 2010 Person of the Year?
Poll: Take a look at this year's candidates (listed in alphabetical order) and give them your rating
PEOPLE
10 Questions for Salman Rushdie (10 Questions)
The author's new book, Luka and the Fire of Life, is out Nov. 16. Salman Rushdie will now take your questions
BRIEFING
The Moment
11|10|10: Jakarta
The World
10 ESSENTIAL STORIES
The Case for Nancy Pelosi's Staying Put (Washington: The Politics Page)
Republicans are celebrating and many Democrats bemoaning Nancy Pelosi's effort to remain in her party's leadership after the crushing midterms. But she may end up having the last laugh, yet again
"Don't Ask" Repeal Hits the Skids (Washington: The Politics Page)
The White House Grapples with a New Reality (White House Memo)
With the boss away, Obama's aides try to make sense of the elections