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A handful of scientists have attempted to study the possibility that praying works through some supernatural factor. One of the most cited examples is a 1988 study by cardiologist Randolph Byrd at San Francisco General Hospital. Byrd took 393 patients in the coronary-care unit and randomly assigned half to be prayed for by born-again Christians. To eliminate the placebo effect, the patients were not told of the experiment. Remarkably, Byrd found that the control group was five times as likely to need antibiotics and three times as likely to develop complications as those who were prayed for.

Byrd's experiment has never been replicated and has come under some criticism for design flaws. A more recent study of intercessory prayer with alcoholics found no benefit, while Elisabeth Targ's study of AIDS patients is still too small to produce significant results.

Science may never be able to pin down the benefits of spirituality. Attempts by Benson and others to do so are like "trying to nail Jell-O to the wall," complains William Jarvis, a public-health professor at California's Loma Linda University and the president of the National Council Against Health Fraud. But it may not be necessary to understand how prayer works to put it to use for patients. "We often know something works before we know why," observes Santa Fe internist Larry Dossey, the author of the 1993 best seller Healing Words.

A TIME/CNN poll of 1,004 Americans conducted last week by Yankelovich Partners found that 82% believed in the healing power of prayer and 64% thought doctors should pray with those patients who request it. Yet even today few doctors are comfortable with that role. "We physicians are culturally insensitive about the role of religion," says David Larson, noting that fewer than two-thirds of doctors say they believe in God. "It is very important to many of our patients and not important to lots of doctors."

Larson would like physicians to be trained to ask a few simple questions of their seriously or chronically ill patients: Is religion important to you? Is it important in how you cope with your illness? If the answers are yes, doctors might ask whether the patient would like to discuss his or her faith with the hospital chaplain or another member of the clergy. "You can be an atheist and say this," Larson insists. Not doing so, he argues, is a disservice to the patient.

Even skeptics such as Jarvis believe meditation and prayer are part of "good patient management." But he worries, as do many doctors, that patients may become "so convinced of the power of mind over body that they may decide to rely on that, instead of doing the hard things, like chemotherapy."

In the long run, it may be that most secular of forces--economics--that pushes doctors to become more sensitive to the spiritual needs of their patients. Increasingly, American medicine is a business, run by large hmos and managed-care groups with a keen eye on the bottom line. Medical businessmen are more likely than are scientifically trained doctors to view prayer and spirituality as low-cost treatments that clients say they want. "The combination of these forces--consumer demand and the economic collapse of medicine--are very powerful influences that are making medicine suddenly open to this direction," observes Andrew Weil, a Harvard-trained doctor and author of Spontaneous Healing.

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