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Historians have been equally unkind, characterizing him as neurotically irresolute at some times and unrealistically stubborn at others. Some attribute his firm anticolonial policy during the American Revolution to outright madness. The findings of Drs. Macalpine and Hunter require a modification of this view to take his physical illness into account. The new evidence may also explain the mysterious deaths of several of his ancestors and collateral relatives, including James I's son Henry and George's sister Caroline Matilda, Queen of Denmark and Norway. Both were rumored to have been poisoned by close relatives. Both actually may have died of the royal malady.