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This is often how medicine works. Our powers outpace our principles and protocols, so that we wake up one day to headlines that a sheep has been successfully cloned and have to figure out what that means for the future of reproduction. In the case of genetic testing, there is little doubt that greater knowledge will bring many blessings, but it comes with costs, literal and emotional, and patients entering this territory with imperfect maps need to reckon with the odds of getting lost.