Bill and Melinda Gates

Ages: 54 and 45
Occupation: Philanthropists
Previous TIME 100 Appearances: 3 and 1, respectively

For years, Microsoft co-founder Bill Gates, along with his wife Melinda, has been giving away his fortune. In the past, the pair focused on issues like education and third-world poverty. Now they're accelerating work in the administration of vaccines, angling to spend $10 billion over the next decade to prevent diseases such as pneumonia and diarrhea.

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