Age: 60
Occupation: Editor in chief of Vogue
Previous TIME 100 Appearances: 0
As the indomitable head of American Vogue for more than two decades, Wintour is the most powerful person in fashion, a point underscored by last year's documentary The September Issue. Her Prada-and-sunglasses-wearing ways may be much lampooned, but it's hard to argue with her success.