Age: 37
Occupation: Comedian, actress, producer, writer
After conquering the male-dominated worlds of stand-up comedy and late-night television, the Chelsea Lately host is taking over the rest of Hollywood. This year, she debuted an NBC sitcom, Are You There, Chelsea? (she plays her own sister), sold out a 26-city tour, had a supporting role in the rom-com This Means War and developed her own publishing imprint. (Did we mention the back-to-back best sellers?) Handler's filter-free comedic style will keep breaking barriers as long as she can keep up her hectic pace.