Age: 41
Occupation: Actress
The ever genuine McCarthy has long been loved for comic roles on television's Gilmore Girls and Mike & Molly (for which she won an Emmy in 2011), but in the past year, the world's affection for her grew as plus-size as Mike and Molly themselves. She hosted Saturday Night Live (really well), propelled Bridesmaids to box-office gold and waltzed down the red carpet as a surprise nominee at the Academy Awards, where hilarity rarely gets a nod. Look for her in Judd Apatow's This Is 40.