Followers: 448K
Sample tweet: "Don't forget to turn the clocks ahead — Charlie Sheen LOSES an hour of lying awake grinding his teeth"
Stand-up comedian turned pundit Bill Maher started his TV career on a show called Politically Incorrect. That tells you most of what you need to know about his comedic stylings and social commentary. The uninhibited medium of Twitter seems custom-built for his pithy outbursts, and if you happen to miss the latest airing of his HBO show Real Time with Bill Maher, just follow @billmaher and you'll get every faux pas punch line in real time.