Her left hand looked grotesque; she was unable to perform even the simplest of household tasks. Mrs. Roland Cesarini, 49, suffered from an advanced case of rheumatoid arthritis and, although aspirin gave occasional relief, she needed surgery if she was to regain the use of her hand and fingers.
In an operating suite at Massachusetts General Hospital in Boston, Mrs. Cesarini took a general anesthetic before Dr. Harilaos Sakellarides, an orthopedic surgeon, began a series of complicated surgical procedures. Arthritis had thickened the connective tissue in Mrs. Cesarini's hand and fingers and twisted...