Scarlett Johansson and Keira Knightley, Vanity Fair
What could be better than two rising Hollywood ingenues posing in the buff with perpetually open-shirted fashion designer Tom Ford? Three rising Hollywood ingenues, which would have been the case if Rachel McAdams didn't bow out of Vanity Fair's cover shoot once she discovered she would be photographed au naturel. But that's not to say the cover of the magazine's annual Hollywood issue was lacking star power. By March 2006, both Scarlett Johansson, who was 21 at the time, and Keira Knightley, then 20, were quickly becoming household names. Pairing them with famous photographer Annie Leibovitz and guest art director Ford turned out to be the perfect formula for media buzz, both good and bad. Three years later, the magazine would spoof its own cover by featuring a preening Paul Rudd next to actors Seth Rogen, Jonah Hill and Jason Segel wearing comically unflattering nude suits.