Courteney Cox and David Arquette, 2010

Courteney Cox and David Arquette have a marriage that defies Hollywood. Or rather, they used to. After 11 years of matrimony, the couple announced on Oct. 11, 2010, that they were undergoing a "trial separation." If the separation becomes permanent, things could get complicated for Cox and Arquette, who have been joint business partners ever since they formed Coquette Productions in 2004. (The company is behind Cox's hit show Cougar Town.)

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