Oprah Winfrey

The talk-show queen doesn't need much more to set her apart from the rest — what with her estimated $2.7 billion fortune and a magic ability to sell books just by glancing at them — but she also has the distinction of being a member of the left-handed club. Since men are more likely to be left-handed than women, that makes Oprah doubly impressive. She's in good company: Other show-biz ladies of the southpaw persuasion include Whoopi Goldberg, Julia Roberts and Angelina Jolie (live-in boyfriend Brad Pitt is also a lefty).

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