OCCUPATION: Susan G. Komen founder
PREVIOUS APPEARANCES ON THE TIME 100: 0
PRO: After her sister's death in 1980, Brinker launched one of the most widely known nonprofits in the country, raising more than $1 billion for breast-cancer research. If you've ever chipped in for a co-worker's fundraising walk, it was probably because of Brinker.
CON: Economic downturns are historically tough on charities.