OCCUPATION: Animation maven
PREVIOUS APPEARANCES ON THE TIME 100: 0
PRO: The creator of Family Guy and American Dad signed a $100 million deal with Fox last year, guaranteeing a few more seasons' worth of singing dogs and arcane Star Wars jokes. Partnered with Google for a series of Web-only cartoons.
CON: Critics of the show claim that Family Guy is nothing but a plotless loop of pop-culture references, though MacFarlane defends the show by noting that Mr. T is a Furby hamburglar on the Good Ship Lollipop.