#3. George Bush and Karl Rove
Nicknamed "Bush's Brain" for his pivotal role in the president's ascendancy to the White House, Rove was also Bush's friend of 34 years. Their friendship seems likely to stay intact, but their 14-year political partnership ended when Rove resigned in August, the object of multiple Congressional investigations. Rove said he was leaving to spend more time with his family. "Karl Rove is moving on down the road," Bush said. "I'll be on the road behind you here in a little bit."
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