TIME.com: What are the possible scenarios that could have caused this disastrous accident on the shuttle's reentry into the Earth's atmosphere?
Jeffrey Kluger: There are three possible scenarios that explain this event. The first, which I believe is the likeliest explanation, would be an aerodynamic structural breakup of the shuttle caused by it rolling at the wrong angle. Remember, after reentry, the shuttle is descending without power, which means astronauts at the controls can't compensate for a loss of attitude by using the engines, they can only do so using the flaps. And that's extremely hard. Astronauts describe piloting the shuttle on reentry as like trying to fly a brick with wings. It's very difficult to operate, and even more so to correct any problems.
A second explanation might be a loss of tiles leading to a burn-through. (The shuttle is covered with heat-resistant tiles to protect the craft and those inside it from burning up in the scorching temperatures caused by the friction of reentry.) But I think that explanation is unlikely, because the tile-loss would have had to have been quite substantial for that to become possible. You'll hear a lot in the next few days about things falling off the shuttle during liftoff. But it often happens that they lose a few tiles, and I'd be surprised if it happened on a scale that could make an accident of this type possible.
The last option is some kind of engine failure leading to fuel ignition. Although the main tanks are mostly empty, there should still be fuel left in the maneuvering tanks. But probably not enough for an explosion that could have caused this breakup.
And just in case anybody was wondering, you can almost certainly rule out terrorism as a cause. This incident occurred well above the range of shoulder-fired missiles. And it would probably be easier to sneak a bomb onto Air Force One than to get one onto the shuttle.
TIME.com: So is reentry the Achilles heel of the shuttle program?
JK: No, the Achilles heel has always been liftoff, and the dangers posed by massive fuel load involved. Reentry has, of course, always been a difficult part of the space program. But this is, in fact, our first fatal accident on reentry. Apollo 13 is remembered as our most difficult ever reentry, but the ship and crew survived. The Soviets lost a crew on reentry in 1970 after an oxygen leak that caused the cosmonauts to suffocate on the way down. Reentry is a very difficult process, but the Russians mastered it in 1961 and we did the same a few years later.
TIME.com: Are shuttle crews trained to respond to the scenarios you've described?
JK: Yes, they're trained to deal with loss of attitude on reentry, and a range of other emergencies. But astronauts are not trained to deal with situations that result in certain death, because that would be a bit like training for what you might do if your car went over a cliff in some situations there simply isn't anything you can do. One irony, though, is that NASA hadn't trained astronauts to deal with the sort of quadruple failure that occurred in Apollo 13, because they assumed that such a scenario would result in certain death. But the astronauts survived.
TIME.com: What are the immediate implications for the space program of Saturday's disaster?
JK: Following the precedent of the Challenger disaster in 1986, it's unlikely that NASA will undertake any further shuttle missions or any other manned space flights for the next two years. One immediate problem, though, is the International Space Station, which currently has a crew of three on board. They might consider one further flight to bring that crew home the other option would be for them to return aboard a Russian Soyuz craft, which isn't the most comfortable or the safest ride. Beyond that, however, the space station is likely to be left unoccupied for a long time. NASA won't want to use the shuttle again until it can establish the cause of today's accident, and fix it. Now that we've lost two shuttles out of a fleet of five, it's even conceivable that the shuttle won't fly again. The shuttle was built as a space truck, and then the International Space Station was built to give it something to do. Both programs are likely to suffer as a result of this disaster.