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There may be a cure for male grouchiness, but the patients have to be very, very grouchy. According to Willis Samson, a physiologist at the University of North Dakota School of Medicine, beneficiaries of the new therapy must suffer from a hormonal disorder that makes them, (ahem) "hypogonadal". The cure: testosterone shots or pills. Though excessive amounts of the hormone hae often been associated with aggressive, antisocial behavior, Samson presented research at the Endocrine Society's annual meeting in Los Angeles today showing that men who have too little of the hormone are less grouchy, nervous and irritable after a booster shot.