DRUGS . . . WRINKLED CREAM

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A Johnson & Johnson subsidiary says it will plead guilty tomorrow to obstructing a federal probe of how it marketed Retin-A, an acne drug commonly prescribed as a wrinkle remover. The firm, Ortho Pharmaceuticals of Raritan, N.J., agreed to pay $7.5 million in fines and dismiss three senior employees who shredded documents sought by investigators. The U.S. Food and Drug Administration launched its investigation in 1991, concerned that Ortho had been promoting Retin-A for a non-approved use as a wrinkle cream.