Diet Restriction: Eat Less, Live Longer?

A few years ago, Harvard researcher Dr. David Sinclair joined the growing ranks of scientists who believe that severely restricting calorie intake can slow down the aging process. Evidence for that surprising phenomenon emerged in the 1930s, when scientists learned that underfed rodents lived up to 40% longer than their well-fed counterparts. The results have since been duplicated in fruit flies, worms, monkeys and other lab animals. And preliminary research on humans suggests that some markers of aging--levels of blood glucose, blood pressure, cholesterol--improve on calorie-restriction (CR) diets.

So Sinclair put himself on the same sort of severe diet that...