The notion of repairing disease-damaged brains with replacement cells is among the most talked-about--and the most audacious--ideas in modern neuroscience. Until now, however, that audacity has been limited to illnesses that attack narrowly circumscribed parts of the brain: the substantia nigra, for example, whose destruction causes Parkinson's disease.
But a paper in the current Proceedings of the National Academy of Sciences suggests that neuroscientists may be getting a little more daring. A team of researchers reports that they've managed to reverse a neural disorder in mice that affects not just a single region of the brain but the entire organ....
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