BRAIN WORK

PICTURES SHED LIGHT ON THE MYSTERY OF SCHIZOPHRENIA

IN A QUIET, DARKENED HOSPITAL ROOM, a 25-year-old man with paranoid schizophrenia lies on a table, his eyes closed, listening to the "voice" that has plagued him for more than two years. The voice is relentless, speaking once every 10 seconds or so. "Don't act stupid," it says in a demeaning tone. "Dirty rotten bastard." Each time the man hears the voice, he clicks a button. Scientists, meanwhile, are monitoring his brain activity. Using a special imaging technique called PET scanning, they take series of pictures every 10 minutes. Later, by matching the timing of the button clicks with the snapshots--744...

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