Medicine: The Quest for a Magic Bullet

A new technique that could help the body to defend itself

When it is invaded by a foreign substance—a virus or bacterium, say, or even the cells from a donated kidney or blood transfusion—the healthy body quickly mobilizes the immune system for a counterattack. Among the forces sent into combat are antibodies, tiny molecular missiles that attach themselves to the intruder's surface and help destroy the invader. They are highly efficient and selective; each antibody is so exquisitely designed that it matches up precisely with only one site on the invader or antigen, almost as if it were a key fitting into...

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