Essay: LSD

Three letters, on a drawing of three cubes, appeared not long ago on a fence at the University of Wisconsin with the slogan: YOUR CAMPUS TRAVEL AGENT—ONE TRIP IS WORTH A THOUSAND WORDS. Just about everyone at Wisconsin knew what kind of "trip" that was: the voyage into "inner space," the flight into or out of the self, provided by LSD.

More than half a century ago, the noted American neurologist, Weir Mitchell, chewed some of the mescal buttons of the peyote cactus and reported that he felt "as if the unseen millions of the...