Metabolism: Gout & the Missing Enzyme

Although gout is no longer caricatured as a comical disease caused by high living and swilling port wine, it is still regarded as an affliction almost exclusively of adult men, many of whom like to think that it is associated with above-average intellectual powers. Maybe so. But the latest medical research, presented last week in Baltimore at the annual meeting of the American Rheumatism Association, shows that at least some cases of gout are closely related to a devastating inherited disease. The malady occurs only in male children, and is marked by cerebral palsy, uncontrollable twitching of the hands,...