Science: Fatigue Fighter

High altitude fliers and factory workers also have their uses as guinea pigs. After long study of fatigue in factory and flight, Drs. Hudson Hoagland and Gregory Pincus of the Worcester Foundation for Experimental Biology last week reported in Science that a hormone-like substance called pregnenolone greatly increases human stamina, not only in the air but at ground level. Unlike most artificial stimulants, pregnenolone apparently has no harmful after effects.

Under the stress of tiring work or a shortage of oxygen, the cortex (outer layer) of the kidneys' adrenal glands secretes unusual amounts of certain hormones known as 17-ketosteroids (containing one...

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