Estrogen Redux

There was a sense of déjà vu surrounding the announcement by the U.S.'s National Institutes of Health (NIH) in March that it had called a halt to a major study of the health effects of long-term estrogen use. Wasn't it already known that hormone-replacement therapy, when administered for more than a couple of years, was a bad idea?

Well, yes and no. Two years ago, the NIH cut short the part of the Women's Health Initiative (WHI) study that looked at the long-term use of a combination treatment including estrogen and progestin. Reason: women in the study were...

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